We estimated the population characteristics of the food effects using NONMEM. Individual pharmacokinetic values were estimated as model-independent (AUC, C max, and T max) and model-dependent ( T lag, K a, K cp, K pc, K el, and V d/ F two-compartment open model with lag time) parameters using the WinNonlin software program. The plasma itraconazole concentration-time data were pooled from four pharmacokinetic studies in 144 healthy subjects. The objectives of this retrospective study were to examine the relationship between the bioavailability of itraconazole and the type of food consumed and to determine the effects of food consumption on the pharmacokinetic parameters following a single oral dose of itraconazole in healthy volunteers.
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